Epigenetic regulation of redox signaling in diabetic retinopathy: Role of Nrf2

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• 作者：Renu A. Kowluru ; ^{rkowluru@med.wayne.edu} ; Manish Mishra
• 关键词：AGEs ; advanced glycation end products ; ARE ; antioxidant response element ; ATP ; adenosine triphosphate ; 5mC ; 5-methyl cytosine ; CBP ; CREB-binding protein ; p300 ; E1A binding protein P300 ; Dnmts ; DNA methyl transferases ; ETC ; electron transport complex ; FAD ; flavin adenine dinucleotide ; GCLC ; glutamate-L-cysteine ligase ; catalytic subunit ; GSH ; glutathione ; GSSG ; oxidized glutathione ; H3K4 ; histone H3 lysine 4 ; H3K4me1 ; mono-methyl H3K4 ; H3K4me2 ; di-methyl H3K4 ; H3K4me3 ; tri-methyl H3K4 ; H3K9 ; hist
• 刊名：Free Radical Biology and Medicine
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：103
• 期：Complete
• 页码：155-164
• 全文大小：837 K
• 卷排序：103

文摘

Diabetes-induced metabolic abnormalities increase cellular oxidative stress. Oxidative stress alters the epigenetic machinery. Epigenetics affects Nrf2-mediated signaling, altering mitochondrial homeostasis. Damaged mitochondria accelerates apoptosis, resulting in diabetic retinopathy.