TGF-β1 accelerates the DNA damage response in epithelial cells via Smad signaling

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TGF-β1 accelerates the DNA damage response in epithelial cells via Smad signaling

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作者：Jeeyong Lee¹ ; Mi-Ra Kim¹ ; Hyun-Ji Kim ; You Sun An ; Jae Youn Yi ; ^{yjy_71@kcch.re.kr" class="auth_mail" title="E-mail the corresponding author}
关键词：TGF-β1 ; DNA damage response ; Smads ; Lig4 ; Radioprotection
刊名：Biochemical and Biophysical Research Communications
出版年：2016
出版时间：5 August 2016
年：2016
卷：476
期：4
页码：420-425
全文大小：1145 K

文摘

•: TGF-β1 pretreatment accelerates γ-radiation-induced DNA damage response.
•: TGF-β1-accelerated DNA damage response is dependent on Smad signaling and DNA Ligase IV.
•: TGF-β1 pretreatment protects epithelial cells from γ-radiation in vivo.

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