New function of exonuclease and highly sensitive label-free colorimetric DNA detection

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New function of exonuclease and highly sensitive label-free colorimetric DNA detection

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作者：Hongbo Li^a ; ^b ; ^{lihongbo112@163.com" class="auth_mail" title="E-mail the corresponding author} ; Suqin Wang^a ; Zaisheng Wu^b ; ^c ; ^{wuzaisheng@163.com" class="auth_mail" title="E-mail the corresponding author} ; Jianguo Xu^c ; Guoli Shen^b ; Ruqin Yu^b ; ^{rqyu@hnu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
关键词：Multifunctional probe ; Label-free ; Colorimetric detection ; New function of exonuclease ; p53 gene
刊名：Biosensors and Bioelectronics
出版年：2016
出版时间：15 March 2016
年：2016
卷：77
期：Complete
页码：879-885
全文大小：1268 K

文摘

•: A colorimetric sensor for p53 gene detection was based on THzyme.
•: The novel multifunctional probe was perfectly designed.
•: The new exonuclease's function was found that exonuclease III can degrade the G-quadruplex structure.
•: This label-free strategy of p53 gene detection is highly sensitive.
•: These observations are helpful for the biomedical diagnosis using highly efﬁcient Thzymes.

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