¹H NMR spectroscopy-guided isolation of new sucrose esters from Physalis alkekengi var. franchetii and their antibacterial activity

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• 作者：Chuan-Yang Zhang ; Jian-Guang Luo ; ^{luojg@cpu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Rui-Huan Liu ; Ru Lin ; Ming-Hua Yang ; Ling-Yi Kong ; ^{cpu_lykong@126.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Physalis alkekengi var. franchetii ; Solanaceae ; Sucrose ester ; Antibacterial activity ; 1H NMR spectroscopy-guided isolation
• 刊名：Fitoterapia
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：114
• 期：Complete
• 页码：138-143
• 全文大小：333 K

文摘

Ten new sucrose esters, physakengoses A–J (1 − 10), were isolated from the aerial parts of Physalis alkekengi var. franchetii under the guidance of ¹H NMR spectroscopy. Their structures were determined by spectroscopic analyses (HRESIMS, 1D and 2D NMR, and ESIMS) and chemical methods. These new compounds were tested for antibacterial activities against Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa and Escherichia coli. Among them, compounds 2 and 5–8 showed potent inhibitory effects against test strains with MIC values ranging from 3.5 to 14.9 μg/mL. These findings may indicate that the P. alkekengi var. franchetii has potential application as an ingredient in pharmaceuticals.