Viminalins A-O: Diverse [3+2] hybrids of acylphloroglucinol and α-phellandrene from the fruits of Callistemon viminalis

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• 作者：Lin Wu ; Ya-Long Zhang ; Xiao-Bing Wang ; Yang-Mei Zhang ; Ming-Hua Yang ; Jun Luo ; ^{luojun1981ly@163.com} ; Ling-Yi Kong ; ^{cpu_lykong@126.com}
• 关键词：Myrtaceae ; Acylphloroglucinols ; Callistemon viminalis ; Cytotoxicity
• 刊名：Tetrahedron
• 出版年：2017
• 出版时间：23 February 2017
• 年：2017
• 卷：73
• 期：8
• 页码：1105-1113
• 全文大小：1259 K
• 卷排序：73

文摘

Viminalins A-O (1–15), a series of new [3+2] hybrids of acylphloroglucinols and α-phellandrene featured a 2,3-dihydrobenzofuran core were isolated from the fruits of Callistemon viminalis. Their structures were established on the basis of extensive analysis of NMR spectra, circular dichroism, and X-ray crystallography. An oxidative [3+2] cycloaddition between acylphloroglucinol and monoterpene was speculated as the key step in the biosynthetic pathway. Bioactivities screen indicated that compound 6 exhibited moderate cytotoxic activity.