Low Density Lipoproteins Amplify Cytokine-signaling in Chronic Lymphocytic Leukemia Cells

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• 作者：Lindsay McCaw^a ; ^c ; Yonghong Shi^a ; Guizhi Wang^a ; You-Jun Li^a ; ^g ; David E. Spaner^a ; ^b ; ^d ; ^e ; ^f ; ^{spanerd@sri.utoronto.ca}
• 关键词：Chronic lymphocytic leukemia ; Janus kinases ; STAT3 ; Ruxolitinib ; Cholesterol ; Lipoproteins ; Lysosomal lipase ; HMGCR ; Nuclear receptors
• 刊名：EBioMedicine
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：15
• 期：Complete
• 页码：24-35
• 全文大小：1268 K
• 卷排序：15

文摘

Slow-growing CLL cells use lysosomal lipase to break low density lipoproteins (LDLs) into free fatty acids and cholesterol. LdL degradation products increase survival of proliferating CLL cells. LDLs decrease oxidative stress and increase plasma membrane cholesterol. LDLs amplify signaling responses to cytokines but not antigens in proliferating CLL cells. Rapidly growing CLL cells, acute leukemia cells, and normal lymphocytes do not exhibit this dependence on LDLs.