Perinuclear Anchoring of H3K9-Methylated Chromatin Stabilizes Induced Cell Fate in C. elegans Embryos
文摘

C. elegans chromodomain protein CEC-4 associates stably with the nuclear envelope

CEC-4 anchors heterochromatin through recognition of methylated H3K9 in embryos

Unlike loss of H3K9 methylation, cec-4 mutant does not alter gene expression

cec-4 loss abrogates the embryo’s ability to maintain an induced muscle cell fate

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