Background
After more than two decades of the AIDS epidemic, the spectrum of HIV-associated vascular diseases has considerably evolved from infectious disease with improved survival, to premature atherosclerosis. As a consequence, acute atherosclerosis complications, such as acute coronary and cerebrovascular syndromes (ACS and CVS) are currently growing. However, only few data are available on HIV-infected patients in the setting of ACS/CVS. The aim of the present study was to determine the prevalence of HIV, as well as the characteristics and hospital case fatality of HIV-infected patients with CVS and ACS.
Methods
From the French nationwide hospital medical information database, data from all the consecutive patients hospitalized in the 1546 French hospital/clinics for CVS and/or ACS from 1st January 2005 to 31st December 2008 were analysed.
Findings
Among the 1.189,043 patients included, the prevalence of HIV infection was similar in CVS (0.21 % ) and ACS (0.19) patients (p = 0.0897). HIV patients were younger, and more frequently male.
When compared to HIV-uninfected patients, case fatality was markedly increased in HIV-infected patients after either CVS (OR (95 % CI): 1.73(1.45?.06)) or ACS (OR (95 % CI): 1.37(1.01?.86)), even after adjustment for sex and age or sex, age, and STEMI, respectively.
Conclusion
| HIV-uninfected
n = 1161124 | HIV Infected
n = 2356 | P |
|---|
| CVS | 636728 (99.79 % ) | 1333 (0.21 % ) | <0.0001 |
| Age (years, mean ¡À SD) | 72.4 ¡À 14.9 | 49.5 ¡À 12.0 | <0.0001 |
| Men | 50.0 % | 73.1 % | <0.0001 |
| Case fatality | 12.2 % | 11.1 % | =0.2351 |
| ACS | 524396(99.81 % ) | 1023(0.19 % ) | <0.0001 |
| Age (years, mean ¡À SD) | 68.9 ¡À 14.1 | 51.7 ¡À 10.7 | <0.0001 |
| Men | 65.4 % | 89.3 % | <0.0001 |
| STEMI | 42.9 % | 57.6 % | <0.0001 |
| Case fatality | 6.6 % | 4.4 % | =0.0041 |
