Many individuals with ASD experience auditory difficulties.
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Exposure to VPA is associated with increased risk of ASD and is used as an animal model of ASD.
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In control rats, exposure to pure tones resulted in clear tonotopic bands of c-Fos-positive neurons in auditory nuclei.
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In VPA-exposed rats, pure tone stimulation resulted in significantly more c-Fos-positive neurons in auditory nuclei.
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VPA-exposure was associated with enlargement and displacement of c-Fos tonotopic bands in auditory brainstem nuclei.
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