Can we prevent Alzheimer's disease? Secondary ¡°prevention¡± trials in Alzheimer's disease

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• 作者：Maria C. Carrillo^a ; ^{maria.carrillo@alz.org} ; H. Robert Brashear^b ; Veronika Logovinsky^c ; J. Michael Ryan^d ; Howard H. Feldman^e ; Eric R. Siemers^f ; Susan Abushakra^g ; Dean M. Hartley^a ; Ronald C. Petersen^h ; Ara S. Khachaturianⁱ ; Reisa A. Sperling^j
• 关键词：Alzheimer's disease ; Prevention ; Diagnosis ; Mild cognitive impairment ; Preclinical Alzheimer's
• 刊名：Alzheimer's Dementia
• 出版年：2013
• 出版时间：March, 2013
• 年：2013
• 卷：9
• 期：2
• 页码：123-131.e1
• 全文大小：235 K

文摘

Current research including the basic biology of Alzheimer's disease (AD) provides a foundation to explore whether our current state of knowledge is sufficient to initiate prevention studies and allow us to believe prevention of AD is possible. Current research and recently revised criteria for the diagnosis of AD by the National Institutes on Aging and the Alzheimer's Association suggest a continuum of disease from preclinical asymptomatic to symptomatic Alzheimer's dementia. In light of these revised criteria, the possibility of secondary prevention and even primary prevention is under discussion. The Alzheimer's Association Research Roundtable convened a meeting to discuss the rationale and feasibility of conducting secondary prevention trials in AD.