A PP2A-B55-Mediated Crosstalk between TORC1 and TORC2 Regulates the Differentiation Response in Fission Yeast

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• 作者：Ruth Martí ; n¹ ; ³ ; Marina Portantier¹ ; ³ ; Nathalia Chica¹ ; Mari Nyquist-Andersen¹ ; Juan Mata² ; Sandra Lopez-Aviles¹ ; ⁴ ; ^{sandra.lopez-aviles@biotek.uio.no}
• 关键词：sexual differentiation ; nitrogen starvation ; TORC1 ; TORC2 ; Gad8 ; PP2A ; B55 ; S. pombe
• 刊名：Current Biology
• 出版年：2017
• 出版时间：23 January 2017
• 年：2017
• 卷：27
• 期：2
• 页码：175-188
• 全文大小：4011 K
• 卷排序：27

文摘

PP2A-B55Pab1 regulates the differentiation response of fission yeast cells PP2A-B55Pab1 enables a crosstalk between TORC1 and TORC2 TORC1 favors PP2A-B55Pab1 activity to prevent the hyperphosphorylation of Gad8 TORC1 inactivation leads to PP2A-B55Pab1 inhibition, activation of Gad8, and differentiation