Human Embryonic Stem Cells Do Not Change Their X Inactivation Status during Differentiation

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• 作者：Sanjeet Patel¹ ; ⁴ ; Giancarlo Bonora¹ ; ⁴ ; Anna Sahakyan¹ ; Rachel Kim¹ ; Constantinos Chronis¹ ; Justin Langerman¹ ; Sorel Fitz-Gibbon² ; Liudmilla Rubbi² ; Rhys J.P. Skelton³ ; Reza Ardehali³ ; Matteo Pellegrini² ; William E. Lowry² ; Amander T. Clark² ; Kathrin Plath¹ ; ⁵ ; ^{kplath@mednet.ucla.edu}
• 关键词：human induced pluripotent stem cells ; human embryonic stem cells ; X-inactivation ; X-chromosome dosage compensation ; Xist ; inactive X chromosome ; Xi-erosion ; DNA methylation
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：3 January 2017
• 年：2017
• 卷：18
• 期：1
• 页码：54-67
• 全文大小：6203 K
• 卷排序：18

文摘

Insights into XCI status during human ESC derivation, propagation, and differentiation Differentiated cells carry the XCI state of the human ESCs they originate from X-to-autosome dosage compensation is not required for human ESC differentiation An XIST-negative XaXa state is an intermediate in the establishment of human XCI