Macrophages from disease resistant B2 haplotype chickens activate T lymphocytes more effectively than macrophages from disease susceptible B19 birds

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• 作者：Ellen Collisson ; Lisa Griggs ; Yvonne Drechsler ; ^{ydrechsler@westernu.edu}
• 关键词：Macrophage ; T lymphocytes ; Major histocompatibility complex ; B haplotype ; Avian influenza virus ; Nucleocapsid protein
• 刊名：Developmental & Comparative Immunology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：67
• 期：Complete
• 页码：249-256
• 全文大小：657 K
• 卷排序：67

文摘

B haplotypes in chickens correlate with resistance to disease. Influenza virus infected macrophages from resistant lines are highly effective at activating T lymphocytes. Cell-cell interactions are not required. Both CD4 and CD8 T lymphocytes respond to infected macrophages. T lymphocyte mitogen stimulation does not correlate with disease.