Increased interleukin-35 expression in tumor-infiltrating lymphocytes correlates with poor prognosis in patients with breast cancer

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• 作者：Zhonghua Zhao^a ; ^b ; Xi Chen^a ; Shengnan Hao^a ; Rui Jia^c ; Nana Wang^d ; Shaoshui Chen^b ; Mianli Li^b ; Chuanxin Wang^e ; Haiting Mao^a ; ^{haitingmao@yahoo.com}
• 关键词：IDC ; invasive ductal carcinoma ; IL-35 ; interleukin-35 ; Tregs ; regulatory T cells ; TILs ; tumor-infiltrating lymphocytes ; EBI3 ; Epstein-Barr Virus (EBV)-induced gene 3 ; Bregs ; regulatory B cells ; PFS ; progression-free survival ; OS ; overall survival ; ER ; estrogen receptor ; PR ; progesterone receptor ; HER2 ; human epithelial growth factor receptor 2 ; EGFR ; Epidermal Growth Factor Receptor ; NSCLC ; non-small cell lung cancer
• 刊名：Cytokine
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：89
• 期：Complete
• 页码：76-81
• 全文大小：2088 K
• 卷排序：89

文摘

IL-35 is expressed in tumor-infiltrating lymphocytes of breast cancer. The expression level of IL-35 in TILs may be a valuable prognostic factor for IDC. High plasma IL-35 levels were associated with late TNM stage in IDC. Increased IL-35+ populations in the TILs may impair antitumor immune response.