Regulation of autophagy by mitochondrial phospholipids in health and diseases

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• 作者：Paul Hsu^a ; Yuguang Shi^b ; ^{shiy4@uthscsa.edu}
• 关键词：ALCAT1 ; lysocardiolipin acyltransferase 1 ; ALE1 ; lysophospholipid acyltransferase (yeast) ; AMPK ; AMP-activated protein kinase ; Atg ; autophagy-related gene ; ATGL ; adipose triglyceride lipase ; AVT1 ; amino acid vacuolar transport ; BNIP3 ; BCL2/adenovirus E1B 19  ; kDa interacting protein 3 ; CCCP ; carbonyl cyanide m-chlorophenyl hydrazine ; CDP-DAG ; CDP-diacylglycerol ; CDS ; phosphatidate cytidylyltransferase 1 ; CGI-58 ; comparative gene identification-589 ; CL ; cardiolipin ; CRD1 ; cardiolipin synthase
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1862
• 期：1
• 页码：114-129
• 全文大小：1531 K
• 卷排序：1862

文摘

Macroautophagy requires mitochondrial phospholipids for optimal function. Pathological cardiolipin remodeling leads to impaired autophagy. Defects in autophagy are implicated in the pathogenesis of aging-related diseases.