Generation of a monkey-tropic human immunodeficiency virus type 1 carrying env from a CCR5-tropic subtype C clinical isolate

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Generation of a monkey-tropic human immunodeficiency virus type 1 carrying env from a CCR5-tropic subtype C clinical isolate

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作者：Hiroyuki Otsuki ; Mai Yoneda ; Tatsuhiko Igarashi ; Tomoyuki Miura ; ^{tmiura@virus.kyoto-u.ac.jp" class="auth_mail}
关键词：Monkey-tropic HIV-1 ; Pig-tailed macaque ; Intracellular homologous recombination ; Primary isolate ; Subtype C ; CCR5 tropism ; in vitro passage ; Animal model ; AIDS ; Restriction factor
刊名：Virology
出版年：July 2014
年：2014
卷：460-461
期：Complete
页码：1-10
全文大小：800 K

文摘

•: We generated a new monkey-tropic HIV-1 carrying CCR5-tropic subtype C env gene.
•: The virus was generated with maintaining variety.
•: The virus was adapted to primary lymphocyte culture of Pig-tailed monkey.
•: Monkey infection with the adapted virus exhibited high peak viremia levels in plasma.

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