Transcriptional and epigenetic phenomena in peripheral blood cells of monozygotic twins discordant for alzheimer’s disease, a case report

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• 作者：Claudio D&rsquo ; Addario^a ; ^b ; ^{cdaddario@unite.it} ; Sussy Bastias Candia^c ; Beatrice Arosio^d ; ^e ; Martina Di Bartolomeo^a ; Carlo Abbate^e ; Alessandra Casè ; ^d ; Sanzio Candeletti^f ; Patrizia Romualdi^f ; Sarah Damanti^e ; ^g ; Mauro Maccarrone^b ; ^h ; ¹ ; Luigi Bergamaschini^d ; ⁱ ; ¹ ; Daniela Mari^d ; ^e ; ¹
• 关键词：AD ; Alzheimer&rsquo ; s Disease ; HADACs ; histone deacetylases ; APP ; amyloid precursor protein ; SIRT1 ; sirtuin 1 ; APOE ; apolipoprotein E ; PSEN1 ; presenilin 1 ; PIN1 ; peptidyl prolyl isomerase 1 ; PBMCs ; peripheral blood mononuclear cells ; DNMTs ; DNA methyltransferases ; Aβ ; Amyloid-β ; Ptau ; Phosphorylated tau ; CSF ; cerebrospinal fluid ; MCI ; Mild Cognitive Impairment ; H3K27me3 ; Histone 3 lysine 27 trimethylated ; H3K4me3 ; Histone 3 lysine 4 trimethylated ; H3K9Ac ; Histone 3 lysine 9 acetylated
• 刊名：Journal of the Neurological Sciences
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：372
• 期：Complete
• 页码：211-216
• 全文大小：315 K
• 卷排序：372

文摘

Target gene expression alterations in monozygotic twins discordant for AD Role of histone acetylation in mediating epigenetic changes in the affected twin Epigenetic mechanisms in peripheral blood mononuclear cells as potential biomarkers in AD