Trans-crocetin improves amyloid-β degradation in monocytes from Alzheimer's Disease patients

详细信息    查看全文

• 作者：Roberto Tiribuzi^a ; ¹ ; Lucia Crispoltoni^b ; ¹ ; Valerio Chiurchiù ; ^c ; ^d ; Antonella Casella^e ; Celeste Montecchiani^e ; Alberto Marco Del Pino^f ; Mauro Maccarrone^c ; ^d ; Carlo Alberto Palmerini^f ; Carlo Caltagirone^g ; ^h ; Toshitaka Kawaraiⁱ ; Aldo Orlacchio^l ; Antonio Orlacchio^b ; ^e ; ^{a.orlacchio@hsantalucia.it}
• 关键词：AD ; Alzheimer's Disease ; Aβ42 ; amyloid-β (1&ndash ; 42) ; CatB ; cathepsin B ; SAD ; sporadic form of Alzheimer's Disease
• 刊名：Journal of the Neurological Sciences
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：372
• 期：Complete
• 页码：408-412
• 全文大小：413 K
• 卷排序：372

文摘

Potential beneficial effect of saffron on AD patients. Trans-crocetin induces amyloid-β(1–42) degradation in monocytes from AD patients. Trans-crocetin enhances cathepsin B levels on cultured monocytes from AD patients.