Evaluation of cytotoxic and genotoxic activity of fungicide formulation Tango^® Super in bovine lymphocytes

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• 作者：Viera Schwarzbacherová ; ^a ; ^{viera.schwarzbacherova@uvlf.sk} ; Maciej Wnuk^b ; Anna Lewinska^c ; Leszek Potocki^b ; Jacek Zebrowski^d ; Marek Koziorowski^e ; Beá ; ta Holečková ; ^a ; Katarí ; na &Scaron ; iviková ; ^a ; Já ; n Dianovský ; ^a
• 关键词：Tango fungicide ; Bovine lymphocytes ; Cytotoxicity ; Genotoxicity ; Oxidative stress
• 刊名：Environmental Pollution
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：220
• 期：part_PA
• 页码：255-263
• 全文大小：1827 K
• 卷排序：220

文摘

Tango® Super cyto- and genotoxicity was examined in cultured bovine lymphocytes. The fungicide provoked apoptotic cell death and mitochondrial superoxide production. Double-strand breaks and p53 binding protein were induced as a result of DNA damage. The fungicide-induced DNA damage was the result of oxidative stress. Oxidative stress may contribute to a higher occurrence of apoptotic cell death.