Factors Associated with Sequelae of Campylobacter and Non-typhoidal Salmonella Infections: A Systematic Review

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• 作者：Oluwaseun B. Esan^a ; ^b ; ^{oluwaseun.esan@phc.ox.ac.uk} ; Madison Pearce^b ; ^c ; Oliver van Hecke^a ; Nia Roberts^d ; Dylan R.J. Collins^a ; Mara Violato^b ; ^e ; Noel McCarthy^b ; ^c ; ^f ; Rafael Perera^a ; ^b ; Thomas R. Fanshawe^a ; ^b
• 关键词：Gastroenteritis ; Campylobacter ; Salmonella ; Sequelae ; Antibiotics ; Acid suppression
• 刊名：EBioMedicine
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：15
• 期：Complete
• 页码：100-111
• 全文大小：580 K
• 卷排序：15

文摘

There is no clear direction of the association between antibiotics and gastroenteritis triggered reactive arthritis. Precision of genomic methods and increased use of record linkage techniques may provide clarity.Antibiotics are known to change the gut flora but little is known of their potential to cause complications in patients who have gastroenteritis. We conducted a systematic review of the existing evidence to assess the potential association of antibiotic usage in patients with gastroenteritis and the occurrence of complications such as reactive arthritis (ReA). The available evidence did not indicate a clear direction in the association of antibiotics and ReA. The lack of clarity in the association of antibiotics and ReA raises a call for further primary research on the role of medications in the development of complications of gastroenteritis.