Bridging-therapy with intravenous recombinant tissue plasminogen activator improves functional outcome in patients with endovascular treatment in acute stroke

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• 作者：Ilko L. Maier^a ; ^{ilko.maier@med.uni-goettingen.de} ; Daniel Behme^b ; Marlena Schnieder^a ; Ioannis Tsogkas^b ; Katharina Schregel^b ; Alexander Kleinknecht^a ; Katrin Wasser^a ; Mathias Bä ; hr^a ; Michael Knauth^b ; Marios Psychogios^b ; Jan Liman^a
• 关键词：Ischemic stroke ; Thrombolysis ; Endovascular treatment ; Acute stroke outcome
• 刊名：Journal of the Neurological Sciences
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：372
• 期：Complete
• 页码：300-304
• 全文大小：212 K
• 卷排序：372

文摘

Bridging with IVT in patients undergoing mechanical thrombectomy was associated with improved neurological function. In patients with bridging therapy with IVT there was a trend towards a higher rate of successful recanalization. Early allocation and systemic effects of IVT on stroke recurrence and penumbra-perfusion might have an influence. Larger trials are needed to confirm our findings and to investigate subgroups benefitting most from bridging with IVT.