Mixing and matching nuclear envelope remodeling and spindle assembly strategies in the evolution of mitosis

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• 作者：Maria Makarova ; Snezhana Oliferenko ^{snezhana.oliferenko@kcl.ac.uk" class="auth_mail" title="E-mail the corresponding author}
• 刊名：Current Opinion in Cell Biology
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：41
• 期：Complete
• 页码：43-50
• 全文大小：1358 K

文摘

In eukaryotes, cellular genome is enclosed inside a membrane-bound organelle called the nucleus. The nucleus compartmentalizes genome replication, repair and expression, keeping these activities separated from protein synthesis and other metabolic processes. Each proliferative division, the duplicated chromosomes must be equipartitioned between the daughter cells and this requires precise coordination between assembly of the microtubule-based mitotic spindle and nuclear remodeling. Here we review a surprising variety of strategies used by modern eukaryotes to manage these processes and discuss possible mechanisms that might have led to the emergence of this diversity in evolution.