Intrathecal injection of P/Q type voltage-gated calcium channel antibodies from paraneoplastic cerebellar degeneration cause ataxia in mice

详细信息    查看全文

• 作者：Elena Mart¨ªn-Garc¨ªa ; Francesco Mannara ; Javier Guti¨¦rrez-Cuesta ; Lidia Sabater ; Josep Dalmau ; Rafael Maldonado ; Francesc Graus
• 关键词：Paraneoplastic cerebellar degeneration ; Lambert&ndash ; Eaton Myasthenic syndrome ; Small-cell lung cancer ; P/Q-type voltage-gated calcium channel antibodies ; Intrathecal injection ; Mouse model
• 刊名：Journal of Neuroimmunology
• 出版年：2013
• 出版时间：15 August, 2013
• 年：2013
• 卷：261
• 期：1-2
• 页码：53-59
• 全文大小：1254 K

文摘

The role of antibodies against the P/Q type voltage-gated calcium channels (VGCC-ab) in the pathogenesis of paraneoplastic cerebellar degeneration (PCD) and lung cancer is unclear. We evaluated in mice the effect of intrathecal injection of IgG purified from serum of a patient with both PCD and Lambert-Eaton myasthenic syndrome (LEMS), and from another patient with isolated LEMS. Mice injected with PCD/LEMS IgG developed marked, reversible ataxia compared with those injected with LEMS or control IgG. These findings suggest that P/Q-type VGCC-ab may play a role in the pathogenesis of ataxia in patients with PCD and SCLC.