Chiral separation of mandelic acid enantiomers using an aqueous two-phase system based on a thermo-sensitive polymer and dextran
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A thermo-sensitive polymer Poly(MAH-β-CD-co-NIPAAm) was synthesized and characterized.

Poly(MAH-β-CD-co-NIPAAm) was both used as chiral selector and phase-forming component of aqueous two-phase system.

ATPS formed by Poly(MAH-β-CD-co-NIPAAm) and dextran T40 was used for chiral separation of mandelic acid enantiomers.

Poly(MAH-β-CD-co-NIPAAm) can be recycled by heating and centrifugation.

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