The HIF1A rs2057482 polymorphism is associated with risk of developing premature coronary artery disease and with some metabolic and cardiovascular risk factors. The Genetics of Atherosclerotic Disease (GEA) Mexican Study

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The HIF1A rs2057482 polymorphism is associated with risk of developing premature coronary artery disease and with some metabolic and cardiovascular risk factors. The Genetics of Atherosclerotic Disease (GEA) Mexican Study

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作者：Alberto Ló ; pez-Reyes^a ; José ; Manuel Rodrí ; guez-Pé ; rez^b ; Javier Ferná ; ndez-Torres^a ; Nancy Martí ; nez-Rodrí ; guez^b ; Nonanzit Pé ; rez-Herná ; ndez^b ; Arturo Javier Fuentes-Gó ; mez^a ; Carlos Alberto Aguilar-Gonzá ; lez^a ; Edith Á ; lvarez-Leó ; n^b ; Carlos Posadas-Romero^c ; Teresa Villarreal-Molina^d ; Carlos Pineda^a ; Gilberto Vargas-Alarcó ; n^b ; ^{gvargas63@yahoo.com" class="auth_mail}
关键词：Cardiovascular risk factors ; Coronary artery disease ; Hypoxia ; Hypoxia-inducible factor 1-alpha ; Ischemia ; Polymorphisms
刊名：Experimental and Molecular Pathology
出版年：June 2014
年：2014
卷：96
期：3
页码：405-410
全文大小：247 K

文摘

•: Three HIF1A polymorphisms were determined in premature CAD patines and healthy controls.
•: The rs2057482 T allele was associated with decreased risk of premature CAD.
•: The rs2057482 T allele was associated with decreased risk of several cardiovascular risk factors.
•: The results suggest that HIF1A rs2057482 polymorphism is involved in the risk of developing CAD.