Activation of Notch3 promotes pulmonary arterial smooth muscle cells proliferation via Hes1/p27Kip1 signaling pathway

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Activation of Notch3 promotes pulmonary arterial smooth muscle cells proliferation via Hes1/p27Kip1 signaling pathway

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作者：Yang Song^a ; Yonghong Zhang^a ; Haoxiang Jiang^b ; Yanting Zhu^a ; Lu Liu^a ; Wei Feng^a ; Lan Yang^a ; Yibin Wang^c ; Manxiang Li^a ; ^{manxiangli@hotmail.com" class="auth_mail" title="E-mail the corresponding author}
关键词：PAH ; pulmonary arterial hypertension ; PAP ; pulmonary arterial pressure ; PASMCs ; pulmonary arterial smooth muscle cells
刊名：FEBS Open Bio
出版年：2015
出版时间：2015
年：2015
卷：5
期：Complete
页码：656-660
全文大小：704 K

文摘

•: Notch3 receptor (NICD3) over-expression induces proliferation of pulmonary arterial smooth muscle cells (PASMCs).
•: NICD3 up-regulates Hes1 expression and reduces p27Kip1 expression.
•: Hes1 mediates NICD3-induced p27Kip1 reduction and proliferation of PASMCs.

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