Distinctive Patterns of Transcription and RNA Processing for Human lincRNAs

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• 作者：Margarita Schlackow¹ ; ³ ; Takayuki Nojima¹ ; ³ ; ^{taka.nojima@path.ox.ac.uk} ; Tomas Gomes² ; Ashish Dhir¹ ; Maria Carmo-Fonseca² ; Nick J. Proudfoot¹ ; ⁴ ; ^{nicholas.proudfoot@path.ox.ac.uk}
• 关键词：mNET-seq ; lincRNA ; splicing ; phosphor CTD marks ; exosome ; transcription termination ; polyadenylation ; CPSF73 ; empigen
• 刊名：Molecular Cell
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：65
• 期：1
• 页码：25-38
• 全文大小：3874 K
• 卷排序：65

文摘

lincRNAs and pre-mRNAs are transcribed by different Pol II phospho-CTD isoforms lincRNAs are rarely spliced and mainly non-polyadenylated lincRNAs are stabilized in the nucleoplasm following exosome inactivation lincRNAs are co-transcriptionally cleaved