Isoxazoles incorporated N-substituted decahydroquinolines: A precursor to the next generation antimicrobial drug

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• 作者：Mariappan Babu ; Kasi Pitchumani ; Penugonda Ramesh ; ^{npc_ramesh@yahoo.co.in}
• 关键词：Decahydroisoxazolo[4 ; 3-c]quinolines ; Agar cup plate method ; Disc diffusion method ; Antifungal activity ; Antibacterial activity
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2012
• 出版时间：January, 2012
• 年：2012
• 卷：47
• 期：Complete
• 页码：608-614
• 全文大小：415 K

文摘

We report here a simple entry into N-substituted decahydroisoxazoloquinoline system with substituents at position 3 and 4 from the readily available substrates for the first time. The synthesized isoxazoloquinolines were evaluated against six bacterial and four fungal strains. The results suggest that the decahydroisoxazolo[4,3-c]quinoline scaffold has the potential to be developed into therapeutically useful antimicrobial agents.