Sickle red cells as danger signals on proinflammatory gene expression, leukotriene B4 and interleukin-1 beta production in peripheral blood mononuclear cell

设为首页

收藏本站

网站地图 | English | 公务邮箱

About the library

Background
History
Leadership
Organization

Readers' Guide

Opening Hours
Collections
Help Via Email

Publications

Electronic Information Resources

Sickle red cells as danger signals on proinflammatory gene expression, leukotriene B4 and interleukin-1 beta production in peripheral blood mononuclear cell

详细信息查看全文

作者：Thassila N. Pitanga^a ; ^b ; Ricardo R. Oliveira^a ; Dalila L. Zanette^a ; Caroline C. Guarda^a ; Rayra P. Santiago^a ; Sanzio S. Santana^a ; Valma M.L. Nascimento^c ; Jonilson B. Lima^a ; Graziele Q. Carvalho^a ; Vitor V. Maffili^a ; Magda O.S. Carvalho^a ; ^d ; Luiz C.J. Alcâ ; ntara^a ; Valé ; ria M. Borges^a ; Marilda S. Goncalves^a ; ^e ; ^{mari@bahia.fiocruz.br" class="auth_mail" title="E-mail the corresponding author}
关键词：AA-PBMC ; peripheral blood mononuclear cells freshly isolated from healthy individuals ; AA-RBC ; red blood cell from healthy individuals ; ASC ; apoptosis-associated speck-Like protein containing card ; DAMPs ; damage-associated molecular pattern molecules (DAMPs) ; HbF ; fetal hemoglobin ; HMGB1 ; high-mobility group protein B1 ; HU ; hydroxyurea ; LT ; leukotriene ; LTB4 ; leukotriene B4 ; NLR ; Nod-like receptors ; NLRP3 ; Nod-like receptor family ; pyrin domain containing 3 ; PAMP ; pathogen-associated molecular p
刊名：Cytokine
出版年：2016
出版时间：July 2016
年：2016
卷：83
期：Complete
页码：75-84
全文大小：1389 K

文摘

•: SCA patients have inflammatory mediator’s levels higher than in healthy controls.
•: RBC from SCA patients induce TLR and NLRP3 inflammasome expression.
•: HU does not prevent NLRP3 inflammasome- and TLR-dependent inflammation.
•: TLR and NLRP3 pathways may be key inducers for inflammation in SCA.