Exosome derived from murine adipose-derived stromal cells: Neuroprotective effect on in vitro model of amyotrophic lateral sclerosis

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Exosome derived from murine adipose-derived stromal cells: Neuroprotective effect on in vitro model of amyotrophic lateral sclerosis

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作者：Roberta Bonafede^a ; Ilaria Scambi^a ; Daniele Peroni^b ; Valentina Potrich^b ; Federico Boschi^c ; Donatella Benati^a ; Bruno Bonetti^a ; Raffaella Mariotti^a ; ^{raffaella.mariotti@univr.it" class="auth_mail" title="E-mail the corresponding author} ; ^{raffaella.mariotti1@gmail.com" class="auth_mail" title="E-mail the corresponding author}
关键词：Mesenchymal stem cell ; Extracellular vesicles ; Paracrine effect ; ALS ; Motoneuron disease ; Motoneuron-like NSC-34
刊名：Experimental Cell Research
出版年：2016
出版时间：1 January 2016
年：2016
卷：340
期：1
页码：150-158
全文大小：8403 K

文摘

•: Hydrogen peroxide was used to induce apoptosis in in vitro model of ALS.
•: NSC-34 cells expressing different ALS mutations were used as in vitro model.
•: Exosomes isolated from adipose stem cells (ASCs) were used as non-cell-based therapy.
•: Exosomes protect motoneuron-like NSC-34 cells from oxidative damage.
•: ASCs-exosomes were able to rescue transfected NSC-34 cells from apoptosis.

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