Forced swimming sabotages the morphological and synaptic maturation of newborn granule neurons and triggers a unique pro-inflammatory milieu in the hippocampus

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Forced swimming sabotages the morphological and synaptic maturation of newborn granule neurons and triggers a unique pro-inflammatory milieu in the hippocampus

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作者：Marí ; a Llorens-Martí ; n ; ^{m.llorens@csic.es" class="auth_mail" title="E-mail the corresponding author} ; Jeró ; nimo Jurado-Arjona ; Marta Boló ; s ; Noemí ; Pallas-Bazarra ; Jesú ; s Á ; vila ; ^{javila@cbm.csic.es" class="auth_mail" title="E-mail the corresponding author}
关键词：Adult hippocampal neurogenesis ; Retrovirus ; Acute stress ; Forced swimming ; Inflammation ; Microglia
刊名：Brain, Behavior, and Immunity
出版年：2016
出版时间：March 2016
年：2016
卷：53
期：Complete
页码：242-254
全文大小：3746 K

文摘

•: Forced swimming impedes morphological and functional maturation of newborn neurons.
•: Forced swimming induces the functional and morphological activation of microglia.
•: Forced swimming triggers an intriguing shift in the hippocampal inflammatory milieu.
•: Molecules altered by the Porsolt test are dysregulated in patients with depression.