TcI, TcII and TcVI Trypanosoma cruzi samples from Chagas disease patients with distinct clinical forms and critical analysis of in vitro and in vivo behavior, response to treatment and infection evolution in murine model

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• 作者：Maykon Tavares de Oliveira^a ; Renata Tupinambá ; Branquinho^a ; ^b ; Glá ; ucia Diniz Alessio^a ; Carlos Geraldo Campos Mello^b ; Ní ; via Carolina Nogueira-de-Paiva^a ; Clá ; udia Martins Carneiro^a ; ^b ; ^e ; Max Jean de Ornelas Toledo^c ; Alexandre Barbosa Reis^a ; ^b ; ^e ; Olindo Assis Martins Martins-Filho^d ; Marta de Lana^a ; ^b ; ^e ; ^{delana@nupeb.ufop.br}
• 关键词：DTU ; discrete typing unit ; TcI ; Trypanosoma cruzi DTU I ; TcII ; Trypanosoma cruzi DTU II ; TcIII ; Trypanosoma cruzi DTU III ; TcI ; V ; Trypanosoma cruzi DTU IV ; TcV ; Trypanosoma cruzi DTU V ; TcVI ; Trypanosoma cruzi DTU VI ; MG ; state of Minas Gerais ; Brazil ; PPP ; pre-patent period ; PP ; patent period ; MPP ; maximum peak of parasitaemia ; DMPP ; day of the maximum peak of parasitemia ; MOR ; mortality ; LIT ; liver infusion tryptose ; PBS ; phophate buffer solution ; rpm ; rotation per minute ; FBE ; blood test fres
• 刊名：Acta Tropica
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：167
• 期：Complete
• 页码：108-120
• 全文大小：2183 K
• 卷排序：167

文摘

TcII samples performed better in vitro essays. TcVI samples performed worst in vitro essays. Response to nifurtimox was not associated to parasite genetic and biology. T. cruzi genetics, in vitro, in vivo biology and human disease are correlated.