Clinical features of Japanese polycythemia vera and essential thrombocythemia patients harboring CALR, JAK2V617F, JAK2Ex12del, and MPLW515L/K mutations

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Clinical features of Japanese polycythemia vera and essential thrombocythemia patients harboring CALR, JAK2V617F, JAK2Ex12del, and MPLW515L/K mutations

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作者：Masahiro Okabe^a ; ¹ ; Hiroki Yamaguchi^a ; ¹ ; ^{y-hiroki@fd6.so-net.ne.jp" class="auth_mail" title="E-mail the corresponding author} ; Kensuke Usuki^b ; Yutaka Kobayashi^c ; Eri Kawata^c ; Junya Kuroda^d ; Shinya Kimura^e ; Kenji Tajika^f ; Seiji Gomi^f ; Nobuyoshi Arima^g ; Sinichiro Mori^h ; Shigeki Itoⁱ ; Masayuki Koizumi^j ; Yoshikazu Ito^k ; Satoshi Wakita^a ; Kunihito Arai^a ; Tomoaki Kitano^a ; Fumiko Kosaka^a ; Kazuo Dan^a ; Koiti Inokuchi^a
关键词：Polycythemia vera ; Essential thrombocythemia ; JAK2 mutation ; MPL mutation ; CALR mutation
刊名：Leukemia Research
出版年：2016
出版时间：January 2016
年：2016
卷：40
期：Complete
页码：68-76
全文大小：1900 K

文摘

•: We assessed the clinical features and genetic mutations of Japanese MPN patients.
•: The clinical features of JAK2V617F and CALR mutation ET differ.
•: We did not find a correlation between CALR mutations and the 46/1 haplotype.
•: CALR mutation ET had a lower incidence of thrombosis relative to JAK2V617F ET.