Usabamycins A¨CC: New anthramycin-type analogues from a marine-derived actinomycete

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• 作者：Seizo  ; Sato  ; ;   ; ^{s-satou@nissui.co.jp} ; Fumie  ; Iwata ; Shoichi  ; Yamada ; Hiroyuki  ; Kawahara ; Masashi  ; Katayama
• 关键词：Marine-derived actinomycete ; Anthramycin ; Usabamycin ; Toxic activity ; Serotonin 5HT inhibitory activity
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2011
• 出版时间：1 December 2011
• 年：2011
• 卷：21
• 期：23
• 页码：7099-7101
• 全文大小：197 K

文摘

New anthramycin-type analogues, designated usabamycin A¨CC (1, 2 and 3), have been isolated from cultures of Streptomyces sp. NPS853, a bacterium found in marine sediments. The structures of the new compounds were established on the basis of extensive spectroscopic analyses including 1D- and 2D-NMR (¹H?sup xmlns="""">1H COSY, HSQC, and HMBC) experiments. The usabamycins show weak inhibition of HeLa cell growth and selective inhibition of serotonin (5-hydroxytrypamine) 5-HT_2B uptake.