T-3256336, a novel and orally available small molecule IAP antagonist, induced tumor cell death via induction of systemic TNF alpha production

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T-3256336, a novel and orally available small molecule IAP antagonist, induced tumor cell death via induction of systemic TNF alpha production

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作者：Hiroyuki Sumi ; ^{hiroyuki.sumi@takeda.com" class="auth_mail" title="E-mail the corresponding author} ; Masakazu Inazuka ; Kentaro Hashimoto ; Tomoyasu Ishikawa ; Sei Yoshida ; Masato Yabuki ; ^{masato.yabuki@takeda.com" class="auth_mail" title="E-mail the corresponding author}
关键词：IAP antagonist ; T-3256336 ; TNFα ; cIAP
刊名：Biochemical and Biophysical Research Communications
出版年：2016
出版时间：14 October 2016
年：2016
卷：479
期：2
页码：179-185
全文大小：1989 K

文摘

•: The baseline TNFα expression correlates with the sensitivity to T-3256336.
•: T-3256336 drastically increases plasma TNFα and other cytokines in mice.
•: TNFα neutralizing antibody attenuates the antitumor efficacy of T-3256336.
•: An efficacy of IAP antagonist in vivo depends on the systemic TNFα production.

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