Synthesis and antimalarial activities of some furoxan sulfones and related furazans

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• 作者：Ubaldina Galli ; Loretta Lazzarato ; Massimo Bertinaria ; Giovanni Sorba ; Alberto Gasco ; Silvia Parapini ; Donatella Taramelli
• 关键词：Plasmodium falciparum ; Nitric oxide ; Antimalarial ; Furoxanyl sulfones
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2005
• 出版时间：December 2005
• 年：2005
• 卷：40
• 期：12
• 页码：1335-1340
• 全文大小：218 K

文摘

Furoxan derivatives bearing a sulfone moiety at position 3 or 4 were synthesized and tested for their antimalarial action on the chloroquine-sensitive D10 and the chloroquine-resistent W2 strains of Plasmodium falciparum. The furazan analogues were considered for comparison. The most active compounds were the products in which the –SO₂R groups are at the 3-position of the furoxan system. These latter substances displayed an antimalarial activity in the μM range, possibly related in part to their ability to release NO.