Baclofen-induced suppression of alcohol deprivation effect in Sardinian alcohol-preferring (sP) rats exposed to different alcohol concentrations

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• 作者：Giancarlo Colombo ; Salvatore Serra ; Giovanni Vacca ; Mauro A.M. Carai and Gian Luigi Gessa
• 刊名：European Journal of Pharmacology
• 出版年：2006
• 出版时间：21 November 2006
• 年：2006
• 卷：550
• 期：1-3
• 页码：123-126
• 全文大小：160 K

文摘

This study investigated the effect of the γ-aminobutyric acid_B (GABA_B) receptor agonist, baclofen, on alcohol deprivation effect (the transient increase in alcohol intake occurring after a period of alcohol abstinence) in Sardinian alcohol-preferring (sP) rats exposed to 4 bottles containing water and 10 % , 20 % , and 30 % (v/v) alcohol, respectively. Acute administration of baclofen (1 mg/kg, i.p.) suppressed both aspects of alcohol deprivation effect: the extra-intake of alcohol and the selection of the highest concentrated alcohol solution. These results suggest that the GABA_B receptor is part of the neural substrate mediating alcohol deprivation in sP rats.