Development of a new polyspecific antivenom for snakebite envenoming in Sri Lanka: Analysis of its preclinical efficacy as compared to a currently available antivenom

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Development of a new polyspecific antivenom for snakebite envenoming in Sri Lanka: Analysis of its preclinical efficacy as compared to a currently available antivenom

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作者：Mauren Villalta^a ; André ; s S&aacute ; nchez^a ; Marí ; a Herrera^a ; Mari&aacute ; ngela Vargas^a ; &Aacute ; lvaro Segura^a ; Maykel Cerdas^a ; Ricardo Estrada^a ; Indika Gawarammana^b ; Dan E. Keyler^c ; ^d ; Kimberly McWhorter^c ; Roy Malleappah^c ; Alberto Alape-Giró ; n^a ; Guillermo Leó ; n^a ; José ; Marí ; a Gutié ; rrez^a ; ^{jose.gutierrez@ucr.ac.cr" class="auth_mail" title="E-mail the corresponding author}
关键词：Snake venoms ; Sri Lanka ; Antivenoms ; Neutralization ; Daboia russelii ; Echis carinatus ; Hypnale hypnale ; Naja naja
刊名：Toxicon
出版年：2016
出版时间：November 2016
年：2016
卷：122
期：Complete
页码：152-159
全文大小：323 K

文摘

•: A new polyspecific freeze-dried antivenom against venoms of Sri Lankan snakes was developed.
•: Antivenom was raised against venoms of Daboia russelii, Echis carinatus, Hypnale hypnale and Naja naja.
•: The new antivenom compares favorably with an Indian antivenom in the neutralization of these venoms.
•: This is the first antivenom to include the venom of Hypnale hypnale in the immunizing mixture.