RNA sequence analyses of r-Moj-DM treated cells: TXNIP is required to induce apoptosis of SK-Mel-28

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RNA sequence analyses of r-Moj-DM treated cells: TXNIP is required to induce apoptosis of SK-Mel-28

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作者：Terri D. McBride ; U. Andrew ; Nicko Ly ; Julio G. Soto ; ^{Julio.Soto@sjsu.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：RNA sequencing ; Recombinant RGD disintegrin ; TXNIP knockdowns ; Cell viability ; TXNIP protein localization
刊名：Toxicon
出版年：2016
出版时间：October 2016
年：2016
卷：121
期：Complete
页码：1-9
全文大小：1120 K

文摘

•: 40 genes were differentially expressed as a result of r-Moj-DM treatment.
•: Expression of 6 pro-apoptotic genes was higher in r-Moj-DN treated cells.
•: TXNIP is involved in the apoptotic induction activated by r-Moj-DM.
•: GST-Moj-DM binding to SK-Mel-28 results in integrin clustering.
•: GST-Moj-DM binding results in TXNIP nuclear translocation.

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