Experimental and molecular dynamics studies showed that CBP KIX mutation affects the stability of CBP:c-Myb complex

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Experimental and molecular dynamics studies showed that CBP KIX mutation affects the stability of CBP:c-Myb complex

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作者：Anne Odoux¹ ; Darren Jindal² ; Tamara C. Tamas ; Benjamin W.H. Lim ; Drake Pollard ; Wu Xu ; ^{wxx6941@louisiana.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：CBP ; CREB binding protein ; MD ; molecular dynamics
刊名：Computational Biology and Chemistry
出版年：2016
出版时间：June 2016
年：2016
卷：62
期：Complete
页码：47-59
全文大小：1528 K

文摘

•: The KIX domain mutant decreased c-Myb-mediated transcription in MEFs.
•: The KIX mutations slightly decreased stability of the CBP:c-Myb complex.
•: The KIX mutations affected two salt bridges between CBP and c-Myb.
•: The KIX mutations affected CBP’s hydrophobic interactions with Leu of c-Myb.
•: Our data suggest that presence of an interacting protein has influence on the structure of a protein.

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