Clinical failure of vancomycin in a dialysis patient with methicillin-susceptible vancomycin-heteroresistant S. aureus

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• 作者：Dahlene N. Fusco ; Elizabeth L. Alex ; er ; Scott A. Weisenberg ; Jose R. Mediavilla ; Barry N. Kreiswirth ; Audrey N. Schuetz ; Stephen G. Jenkins ; Kyu Y. Rhee
• 关键词：Vancomycin ; Heteroresistance ; Failure ; Staphylococcus aureus
• 刊名：Diagnostic Microbiology and Infectious Disease
• 出版年：2009
• 出版时间：October 2009
• 年：2009
• 卷：65
• 期：2
• 页码：180-183
• 全文大小：504 K

文摘

We report a case of recurrent Staphylococcus aureus bacteremia in a patient who failed vancomycin due to a vancomycin-heteroresistant strain lacking methicillin resistance. Although initial isolates were susceptible, isolates obtained after vancomycin chemotherapy were vancomycin heteroresistant. This case thus illustrates the clinical emergence of vancomycin heteroresistance.