Binding of inferred germline precursors of broadly neutralizing HIV-1 antibodies to native-like envelope trimers

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Binding of inferred germline precursors of broadly neutralizing HIV-1 antibodies to native-like envelope trimers

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作者：Kwinten Sliepen^a ; ¹ ; ^{k.h.sliepen@amc.uva.nl" class="auth_mail" title="E-mail the corresponding author} ; Max Medina-Ramí ; rez^a ; ¹ ; ^{j.m.medinaramirez@amc.uva.nl" class="auth_mail" title="E-mail the corresponding author} ; Anila Yasmeen^b ; ^{yasmeenanila1@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; John P. Moore^b ; ^{pek2003@med.cornell.edu" class="auth_mail" title="E-mail the corresponding author} ; Per Johan Klasse^b ; ^{jpm2003@med.cornell.edu" class="auth_mail" title="E-mail the corresponding author} ; Rogier W. Sanders^a ; ^b ; ^{r.w.sanders@amc.uva.nl" class="auth_mail" title="E-mail the corresponding author}
关键词：Broadly neutralizing antibodies ; Germline ; HIV-1 ; Env ; SOSIP ; Vaccine
刊名：Virology
出版年：2015
出版时间：December 2015
年：2015
卷：486
期：Complete
页码：116-120
全文大小：684 K

文摘

•: HIV-1 envelope glycoproteins (Env) usually do not interact with the inferred germline precursors of bNAbs.
•: Some inferred germline precursors of bNAbs bind to soluble native-like SOSIP.664 Env trimers.
•: SOSIP.664 trimers present a platform to target germline precursors of bNAbs.

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