The Spectrum and Regulatory Landscape of Intestinal Innate Lymphoid Cells Are Shaped by the Microbiome

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The Spectrum and Regulatory Landscape of Intestinal Innate Lymphoid Cells Are Shaped by the Microbiome

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作者：Meital Gury-BenAri¹ ; ¹⁰ ; Christoph A. Thaiss¹ ; ¹⁰ ; Nicolas Serafini² ; ³ ; Deborah R. Winter¹ ; Amir Giladi¹ ; David Lara-Astiaso¹ ; Maayan Levy¹ ; Tomer Meir Salame⁴ ; Assaf Weiner¹ ; Eyal David¹ ; Hagit Shapiro¹ ; Mally Dori-Bachash¹ ; Meirav Pevsner-Fischer¹ ; Erika Lorenzo-Vivas¹ ; Hadas Keren-Shaul¹ ; Franziska Paul¹ ; Alon Harmelin⁵ ; Gé ; rard Eberl⁶ ; ⁷ ; Shalev Itzkovitz⁸ ; Amos Tanay⁹ ; James P. Di Santo² ; ³ ; Eran Elinav¹ ; ^{eran.elinav@weizmann.ac.il" class="auth_mail" title="E-mail the corresponding author} ; Ido Amit¹ ; ¹¹ ; ^{ido.amit@weizmann.ac.il" class="auth_mail" title="E-mail the corresponding author}
关键词：innate lymphoid cells ; epigenome ; single-cell transcriptomics ; microbiota
刊名：Cell
出版年：2016
出版时间：25 August 2016
年：2016
卷：166
期：5
页码：1231-1246.e13
全文大小：10957 K

文摘

•: Transcriptional and chromatin landscapes of innate lymphoid cells
•: Functional compartmentalization within ILC subsets revealed by single-cell RNA-seq
•: Impact of commensal microbiota on epigenetic regulation and gene expression of ILCs
•: Single-cell analysis of whole-transcriptome responses to microbial colonization

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