• 作者：F. Garcí ; a-Candel ; A. Melero Amor ; J. Gó ; mez-Espuch ; J.M. Moraleda Jimé ; nez
• 关键词：Linfocitosis ; Virus de Epstein-Barr ; Monoclonal ; Citometrí ; a de flujo ; Frotis de sangre perifé ; rica
• 刊名：Medicine - Programa de Formaci¨®n M¨¦dica Continuada Acreditado
• 出版年：2012
• 出版时间：November, 2012
• 年：2012
• 卷：11
• 期：21
• 页码：1317-1320
• 全文大小：863 K

The lymphocytosis can be classified as acute or chronic depending on the rapidity of onset, in primary and secondary or reactive according to etiology, and finally by its polyclonal or monoclonal nature. The initial diagnostic work-up of a persistent lymphocytosis requires performing a thorough medical history and a review of the peripheral blood smear. It is essential to perform diagnostic test to rule out infectious causes (mononucleosis syndromes are the most common) and the study of peripheral blood immunophenotype for lymphocyte subtypes characterization and study of clonality of the expanded population. The presence of monoclonal lymphocytosis usually reflects a lymphoproliferative disease (chronic lymphocytic leukemia is the most common), and requires a bone marrow study and a lymph node biopsy if the patient presents with lymphadenopathies.