Cytokine-Induced Memory-Like Differentiation Enhances Unlicensed Natural Killer Cell Antileukemia and FcγRIIIa-Triggered Responses

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• 作者：Julia A. Wagner ; Melissa M. Berrien-Elliott ; Maximillian Rosario ; Jeffrey W. Leong ; Brea A. Jewell ; Timothy Schappe ; Sara Abdel-Latif ; Todd A. Fehniger ; ^{tfehnige@wustl.edu}
• 关键词：NK cell ; Adoptive immunotherapy ; Cytokines ; NK cell education ; NK cell memory
• 刊名：Biology of Blood and Marrow Transplantation
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：23
• 期：3
• 页码：398-404
• 全文大小：1461 K
• 卷排序：23

文摘

Cytokine-induced memory-like NK cell differentiation enhances NK cell responses. Memory-like differentiation augments licensed and unlicensed NK cell function. Unlicensed NK cell antitumor responses are restored via memory-like differentiation. FcγRIIIa stimulates enhanced IFN-γ production and killing by memory-like NK cells. Mechanisms of memory-like functionality are distinct from human cytomegalovirus–adapted NK cells.