Structural Basis for the Magnesium-Dependent Activation and Hexamerization of the Lon AAA+ Protease
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文摘
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Mg2+-activated LonA forms an open hexameric chamber without nucleotide

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Mg2+-activated LonA degrades unfolded protein or peptides without ATP

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A 1.85 Å structure of the LonA-bortezomib complex reveals the Mg2+-binding site

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Binding of Mg2+ drives the formation of an extended loop at the hexameric interface

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