H<sub>2</sub>S-induced S-sulfhydration of pyruvate carboxylase contributes to gluconeogenesis in liver cells

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H₂S-induced S-sulfhydration of pyruvate carboxylase contributes to gluconeogenesis in liver cells

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作者：YoungJun Ju^a ; Ashley Untereiner^a ; ^b ; Lingyun Wu^a ; ^b ; Guangdong Yang^a ; ^c ; ^{gyang2@laurentian.ca" class="auth_mail" title="E-mail the corresponding author}
关键词：3-MPST ; 3-mercaptopyruvate sulfurtransferase ; CSE ; cystathionine gamma-lyase ; DMEM ; Dulbecco's Modified Eagle's medium ; DTT ; dithiothreitol ; H2S ; hydrogen sulfide ; HFD ; high fat diet ; MMTS ; methyl methanethiosulfonate ; KO ; knockout ; NADH ; reduced nicotinamide adenine dinucleotide ; NAD+ ; oxidized nicotinamide adenine dinucleotide ; PBS ; phosphate buffered saline ; PC ; pyruvate carboxylase ; WT ; wild type
刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
出版年：2015
出版时间：November 2015
年：2015
卷：1850
期：11
页码：2293-2303
全文大小：1473 K

文摘

•: H₂S stimulates PC activity and gluconeogenesis in liver cells.
•: H₂S S-sulfhydrated PC in a dithiothreitol-sensitive way.
•: Cysteine-265 is essential for H₂S-induced PC S-sulfhydration and activity.
•: High-fat diet decreased both CSE expression and PC S-sulfhydration in mouse liver.

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