Epigenetic modifications in colorectal cancer: Molecular insights and therapeutic challenges

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Epigenetic modifications in colorectal cancer: Molecular insights and therapeutic challenges

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作者：Aristeidis G. Vaiopoulos¹ ; Kalliopi Ch. Athanasoula¹ ; Athanasios G. Papavassiliou ; ^{papavas@med.uoa.gr" class="auth_mail}
关键词：5-FU ; fluorouracil ; A ; acetyl-groups ; ALDH1 ; aldehyde dehydrogenase-1 ; AP-1 ; activator protein 1 ; APC ; adenomatous polyposis coli ; ASO ; anti-sense oligonucleotides ; Bmi1 ; B lymphoma Mo-MLV insertion region 1 homolog ; BMP ; bone morphogenetic protein ; CSC ; cancer stem cell ; CBP ; CREB-binding protein ; CDH1 ; cadherin-1 ; CDKN2A ; cyclin-dependent kinase inhibitor 2A ; CDX1 ; caudal type homeobox-1 ; CGI ; CpG islands ; CIMP ; CpG island methylator phenotype ; CIN ; chromosomal instability ; CpG ; cytosine guani
刊名：Biochimica et Biophysica Acta (BBA)/Molecular Basis of Disease
出版年：July 2014
年：2014
卷：1842
期：7
页码：971-980
全文大小：795 K

文摘

•: Epigenetic modifications are responsible for aberrant gene expression in cancer.
•: Epigenetics are involved in various aspects of colorectal carcinogenesis.
•: Biomarkers based on DNA methylation gene patterns are already clinically available.
•: Epigenetics offer alternative rational therapeutic targets in solid tumors.

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