Inhibition of human norovirus by a viral polymerase inhibitor in the B cell culture system and in the mouse model

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Inhibition of human norovirus by a viral polymerase inhibitor in the B cell culture system and in the mouse model

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作者：Abimbola O. Kolawole^a ; Joana Rocha-Pereira^b ; Michael D. Elftman^c ; Johan Neyts^b ; Christiane E. Wobus^a ; ^{cwobus@umich.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：Human norovirus ; Polymerase inhibitor ; Positive-sense RNA virus ; Enteric virus ; Antiviral
刊名：Antiviral Research
出版年：2016
出版时间：August 2016
年：2016
卷：132
期：Complete
页码：46-49
全文大小：452 K

文摘

•: The polymerase inhibitor 2′-C-methylcytidine inhibits HuNoV replication in the recently established B cell culture system.
•: 5">The nucleoside analogue 2′-C-methylcytidine inhibits HuNoV replication in a mouse model of HuNoV infection.
•: Both models show promise for future study and development of antiviral drugs for the treatment of HuNoV infections.

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