Reelin expression is up-regulated in mice colon in response to acute colitis and provides resistance against colitis

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• 作者：Ana E. Carvajal ; Marí ; a D. Vá ; zquez-Carretero ; Pablo Garcí ; a-Miranda ; Marí ; a J. Peral ; Marí ; a L. Calonge ; ^{calonge@us.es} ; Anunciació ; n A. Ilundain
• 关键词：α-SMA ; α-smooth muscle actin ; ApoER2 ; apolipoprotein E receptor 2 ; CASK ; calcium/calmodulin-dependent serine protein kinase ; Dab1 ; Disabled-1 ; DSS ; dextran sulphate sodium ; DNMT1 ; (DNA (Cytosine-5-)-Methyltransferase 1) ; IL-1β ; interleukin-1β ; PDGF-BB ; platelet derived growth factor β ; TGF-β1 ; transforming growth factor β1 ; TNF-α ; tumour necrosis factor α ; Sp1 ; transcription factor Sp1 ; Tbr1 ; T-box brain 1 ; VLDLR ; very low-density lipoprotein receptor
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：1863
• 期：2
• 页码：462-473
• 全文大小：1772 K
• 卷排序：1863

文摘

Reelin expression is restricted to myofibroblasts. DSS-colitis activates reelin production. DSS-colitis decreases DNMT1 expression. DSS-colitis decreases the methylation of the reelin promoter region. Reelin protects from development of acute colitis.